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The insulin index is an identical, more recent classification methodology that ranks foods based on their results on blood insulin ranges, that are attributable to glucose (or starch) and a few amino acids in meals. It has potency in between that of ketamine and phencyclidine however with somewhat more sedating results in animal research.
4-Keto-PCP is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. One of many reactions KDPG Aldolase catalyzes, as in the Entner-Doudoroff pathway, is the reversible cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) into pyruvate and D-glyceraldehyde-3-phosphate.
KDPG aldolase has limited utility attributable to its high specificity for its natural substrates within the cleavage of KDPG and the reverse addition of D-glyceraldehyde-3-phosphate and pyruvate. In vitro evolution has allowed KDPG aldolase to be converted right into a more efficient aldolase with altered substrate specificity and stereoselectivity thereby bettering its utility in asymmetric synthesis.
It's then converted to a succinyl CoA by a carboxylation response and generates additional 5 ATP (1 ATP is consumed in carboxylation process producing a net of four ATP).

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